BS Chemical Engineering Purdue University 1968
PhD Organic Chemistry Purdue University 1972
Postdoctoral Work Columbia University 1972-74
Postdoctoral Work University of Colorado 1974-75
Specialty: Organic synthesis, drug design,
Research Projects: Total synthesis of cannabinoid analogs as potential anti-inflammatory and anti-cancer agents.
Our research concerns the synthesis of pharmacologically-active compounds. In particular, our primary targets are analogs of compounds found in marijuana, a general area which has occupied about 35 years. Currently, there are several particular compounds of interest whose activities include anti-inflammatory (pain relief), anti-cancer, and anti-convulsant properties. Other projects being pursued include those aimed at the preparation and reactions of compounds containing cyclopropane groups and others with significance in agricultural chemistry. One additional area of interest is a project aimed at the removal of heavy metals from wastewater. This is being done in collaboration with the Purdue Water Institute.
Publications: A Novel Approach to the Synthesis of the Cannabinoids, W. E. Childers, Jr. and H. W. Pinnick, J. Org. Chem., 49, 5276 (1984).
Synthesis of 2-Acetylbicyclo[2.2.1]hept-2-ene, L. Cornelius, R. G. A. Bone, R. Hastings, M. A. Deardorff, R. A. Scharlach, B. E. Hauptmann, C. J. Stankovic, and H. W. Pinnick, J. Org. Chem., 58, 3188 (1993).
Outreach or Other Creative Activities: Advisor for Chemistry and Physics Club who sponsor tours, campus events such as liquid nitrogen ice cream, and is planning outreach to area high schools.