Barbara Mania-Farnell, Ph.D.

Barbara Mania-Farnell

Office: Gyte 285

Telephone: (219) 989-2014 
Email: bmania@purduecal.edu

Education

Ph.D. Neurobiology and Physiology, Northwestern University, Evanston, Il
M.S. Social Sciences, University of Chicago, Chicago, Il

Research Interests

I am currently working in collaboration with Dr. Chandra S. Mayanil (Director of Neural Tube Research) at Children’s Memorial Hospital, affiliated with Northwestern University Feinberg School of Medicine. The project I am working on focuses on the role of the transcription factors in neural tube development and neural crest cell differentiation.

Professional Society Memberships

Society for Neuroscience

Publications:

Xi G, Rajaram V, Mania-Farnell B, Mayanil CS, Soares MB, Tomita T, Goldman S. (2012) Efficacy of vincristine administered via convection-enhanced delivery in a rodent brainstem tumor model documented by bioluminescence imaging. Childs Nerv Syst. 2012 Apr;28(4):565-74. Epub 2012 Jan 27.

Ichi S, Nakazaki H, Boshnjaku V, Singh RM, Mania-Farnell B, Xi G, McLone DG, Tomita T, Mayanil CS. (2012) Fetal neural tube stem cells from Pax3 mutant mice proliferate, differentiate, and form synaptic connections when stimulated with folic acid. Stem Cells Dev. 2012 Jan 20;21(2):321-30. Epub 2011 Jun 9.

Xi G, Mania-Farnell B, Rajaram V, Mayanil CS, Soares MB, Tomita T, Goldman S. (2012) Efficacy of interstitial continuous vincristine infusion in a bioluminescent rodent intracranial tumor model. J Neurooncol. Jan;106(2):261-70. Epub 2011 Aug 14.

Mayanil CS, Ichi S, Farnell BM, Boshnjaku V, Tomita T, McLone DG.(2011) Maternal intake of folic acid and neural crest stem cells. Vitam Horm. 87:143-73. Review.

Boshnjaku V, Ichi S, Shen YW, Puranmalka R, Mania-Farnell B, McLone DG, Tomita T, Mayanil CS.  (2011) Epigenetic regulation of sensory neurogenesis in the dorsal root ganglion cell line ND7 by folic acid. Epigenetics. Oct 1;6(10):1207-16. Epub 2011 Oct 1.

Ichi S., Boshnjaku V., Shen Y., Mania-Farnell B.,Sapur S., Mansukhani N., McLone D., Tadanori T., and Mayanil CS. (2011)  Role of Pax3 acetylation in the regulation of Hes1 and Neurog2. Mol Biol Cell Feb 22 (4) Epub 2010 Dec 17.

Ichi S., Costa, FF., Bischof JM., Nakazaki H., Shen YW., Boshnjaku V., Sarma S., Mania-Farnell B., McLone DG., Tomita T., Soares MB., Mayanil CS. (2010) Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development. J. Biol. Chem. 2010 Nov. 19:285(47):36922-32. Epub 2010 Sep 10

Kondo A, Goldman S, Lulla RR, Mania-Farnell B, Vanin EF, Sredni ST, Rajaram V, Soares MB, Tomita T. J Neurosurg Pediatr. (2009) Longitudinal assessment of regional directed delivery in a rodent malignant glioma model. J Neurosurg Pediatr. Dec;4(6):592-8

Tange Y, Kondo A, Egorin MJ, Mania-Farnell B, Daneriallis GM, Nakazaki H, Sredni ST, Rajaram V, Goldman S, Soares MB, Tomita T.  (2009) Interstitial continuous infusion therapy in a malignant glioma model in rats. Childs Nerv Syst. 2009 Jun;25(6):655-62.

Nakazaki H, Shen YW, Yun B, Reddy A, Khanna A, Mania-Farnell B, Ichi S, McLone DG, Tomita T, Mayanil CS. (2009) Transcriptional regulation by Pax3 and TGFbeta2 signaling: a potential gene regulatory network in neural crest development.  (2009) Int J. Dev Biol. 53(1):69-79.

Nakazaki, H, Reddy, AC, Mania-Farnell, BL, Shen, Y, McCabe, C, Ichi, S, George., D, McLone, DG, Tomita, T. (2008) Key basic helix-loop-helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development.  Dev Biol., 316(2):510-23.

Mayanil CS, Pool A, Nakazaki H, Reddy AC, Mania-Farnell B, Yun B, George D, McLone DG, Bremer EG. Regulation of murine TGFbeta2 by Pax3 during early embryonic development. J Biol Chem. 2006 Aug 25;281(34):24544-52. Epub 2006 Jun 19. PMID: 16787918 [PubMed – indexed for MEDLINE]

Miljan EA, Meuillet EJ, Mania-Farnell B, George D, Yamamoto H, Simon HG, Bremer EG. Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides. J Biol Chem. 2002 Mar 22;277(12):10108-13. Epub 2002 Jan 16. PMID: 11796728 [PubMed – indexed for MEDLINE]

Mayanil CS, George D, Freilich L, Miljan EJ, Mania-Farnell B, McLone DG, Bremer EG. Microarray analysis detects novel Pax3 downstream target genes. J Biol Chem. 2001 Dec 28;276(52):49299-309. Epub 2001 Oct 5. PMID: 11590174 [PubMed – indexed for MEDLINE]

Mayanil CS, George D, Mania-Farnell B, Bremer CL, McLone DG, Bremer EG. Overexpression of murine Pax3 increases NCAM polysialylation in a human medulloblastoma cell line. J Biol Chem. 2000 Jul 28;275(30):23259-66. PMID: 10770948 [PubMed – indexed for MEDLINE]

Meuillet EJ, Mania-Farnell B, George D, Inokuchi JI, Bremer EG. Modulation of EGF receptor activity by changes in the GM3 content in a human epidermoid carcinoma cell line, A431. Exp Cell Res. 2000 Apr 10;256(1):74-82. PMID: 10739654 [PubMed – indexed for MEDLINE]

Meuillet EJ, Wiernsperger N, Mania-Farnell B, Hubert P, Cremel G. Metformin modulates insulin receptor signaling in normal and cholesterol-treated human hepatoma cells (HepG2). Eur J Pharmacol. 1999 Jul 21;377(2-3):241-52. PMID: 10456437 [PubMed – indexed for MEDLINE]

Courses

  • BIOL 10700 – Freshman Experience in Biological Sciences
  • BIOL 21300 – Anatomy and Physiology I
  • BIOL 52500 – Principles of Neurobiology
  • BIOL 56600 – Developmental Biology
  • BIOL 59500 – Biology Ethical Frontiers 
  • BIOL 59500 – Epigenetics 
  • SCI 10500 – Human Biology
  • SCI 11400 – Introduction to Life Sciences